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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8288371 B1

PDFFull Text
Date of Patent:
Oct. 16, 2012

Filed:

Oct. 03, 2008

Ortho pyrrolidine, benzyl-substituted heterocycle ccr1 antagonists for autoimmune diseases and inflammation

Applicants:

Vidyadhar M. Paradkar, Somerville, NJ (US);

Marc Brescia, Cranbury, NJ (US);

Ray James, Bensalem, NJ (US);

Jinqi Liu, Plainsboro, NJ (US);

Ruiyan Liu, Yardley, PA (US);

James Robert Merritt, Ewing, NJ (US);

Michelle Morris, Lawrenceville, NJ (US);

Michael J. Ohlmeyer, Plainsboro, NJ (US);

Chongwu Zhang, Dayton, NJ (US);

Rui Zhang, Plainsboro, NJ (US);

Inventors:

Vidyadhar M. Paradkar, Somerville, NJ (US);

Marc Brescia, Cranbury, NJ (US);

Ray James, Bensalem, NJ (US);

Jinqi Liu, Plainsboro, NJ (US);

Ruiyan Liu, Yardley, PA (US);

James Robert Merritt, Ewing, NJ (US);

Michelle Morris, Lawrenceville, NJ (US);

Michael J. Ohlmeyer, Plainsboro, NJ (US);

Chongwu Zhang, Dayton, NJ (US);

Rui Zhang, Plainsboro, NJ (US);

Assignee:

Pharmacopeia, LLC, San Diego, CA (US);

Attorney:

Knobbe, Martens, Olson & Bear LLP

Primary Examiner:

Joseph K McKane

Assistant Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
A61K 31/4196 (2006.01); A61K 31/44 (2006.01); A61K 31/433 (2006.01); A61K 31/42 (2006.01); A61K 31/425 (2006.01); A61K 31/445 (2006.01); A61K 31/4164 (2006.01); A61K 31/40 (2006.01); A61K 31/505 (2006.01); A61K 31/4245 (2006.01); A61K 31/538 (2006.01); C07D 249/08 (2006.01); C07D 401/14 (2006.01); C07D 285/04 (2006.01); C07D 261/06 (2006.01); C07D 277/20 (2006.01); C07D 233/54 (2006.01); C07D 209/02 (2006.01); C07D 413/14 (2006.01); C07D 403/14 (2006.01); C07D 271/08 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.

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