The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2012
Filed:
Feb. 25, 2002
Marcello Allegretti, L'Aquila, IT;
Riccardo Bertini, L'Aquila, IT;
Valerio Berdini, L'Aquila, IT;
Cinzia Bizzarri, L'Aquila, IT;
Maria Candida Cesta, L'Aquila, IT;
Vito Di Cioccio, L'Aquila, IT;
Gianfranco Caselli, L'Aquila, IT;
Fracesco Colotta, L'Aquila, IT;
Carmelo Gandolfi, L'Aquila, IT;
Janete Peloia Barroso Gandolfi, Legal Representative, Milan, IT;
Giulio Agostino Gandolfi, Legal Representative, Milan, IT;
Maria Carla Gandolfi, Legal Representative, Milan, IT;
Arrigo Aldo Gandolfi, Legal Representative, Saronno, IT;
Marcello Allegretti, L'Aquila, IT;
Riccardo Bertini, L'Aquila, IT;
Valerio Berdini, L'Aquila, IT;
Cinzia Bizzarri, L'Aquila, IT;
Maria Candida Cesta, L'Aquila, IT;
Vito Di Cioccio, L'Aquila, IT;
Gianfranco Caselli, L'Aquila, IT;
Fracesco Colotta, L'Aquila, IT;
Carmelo Gandolfi, L'Aquila, IT;
Janete Peloia Barroso Gandolfi, legal representative, Milan, IT;
Giulio Agostino Gandolfi, legal representative, Milan, IT;
Maria Carla Gandolfi, legal representative, Milan, IT;
Arrigo Aldo Gandolfi, legal representative, Saronno, IT;
Dompé Pha.R.Ma S.p.A., L'Aquila, IT;
Abstract
(R)-2-Arylpropionamide compounds of formula (I) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The 2-Arylpropionamides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear leukocytes (leukocytes PMN) and of monocytes at the inflammatory sites. In particular, the invention relates to the R enantiomers of omega-aminoalkylamides of 2-aryl propionic acids, of formula (I), for use in the inhibition of the chemotaxis of neutrophils and monocytes induced by the C5a fraction of the complement and by other chemotactic proteins whose biological activity is associated with activation of a 7-TD receptor. Selected compounds of formula (I) are dual inhibitors of both the C5a-induced chemotaxis of neutrophils and monocytes and the IL-8-induced chemotaxis of PMN leukocytes. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, rheumatoid arthritis and in the prevention and the treatment of injury caused by ischemia and reperfusion.