The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2012
Filed:
Jul. 13, 2007
John R. Havens, San Diego, CA (US);
Thomas J. Onofrey, San Marcos, CA (US);
Charles H. Greef, Ramona, CA (US);
Gregory J. Kevorkian, Temecula, CA (US);
Jain Krotz, San Diego, CA (US);
Kristie L. Lykstad, San Diego, CA (US);
Daniel E. Raymond, San Diego, CA (US);
Howard R. Reese, Poway, CA (US);
Regina Rooney, La Jolla, CA (US);
John J. Scott, Lafayette, IN (US);
John R. Havens, San Diego, CA (US);
Thomas J. Onofrey, San Marcos, CA (US);
Charles H. Greef, Ramona, CA (US);
Gregory J. Kevorkian, Temecula, CA (US);
Jain Krotz, San Diego, CA (US);
Kristie L. Lykstad, San Diego, CA (US);
Daniel E. Raymond, San Diego, CA (US);
Howard R. Reese, Poway, CA (US);
Regina Rooney, La Jolla, CA (US);
John J. Scott, Lafayette, IN (US);
Gamida for Life B.V., Rotterdam, NL;
Abstract
Methods of addressing a biomolecule to a selectively addressable electrode are described. A permeation layer overlying a plurality of selectively addressable electrodes is provided. The permeation layer includes a reactive group that is adapted to bond to a biomolecule and that requires activation through a chemical transformation before bonding to the biomolecule. At least one selectively addressable electrode is biased such that a pH change occurs in an overlying solution of the at least one selectively addressable electrode. The reactive group in a portion of the permeation layer above the at least one selectively addressable electrode is then chemically transformed to an activated reactive group as a result of the pH change. A biomolecule is then bound to the permeation layer overlying the at least one selectively addressable electrode through the activated reactive group.