The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2012
Filed:
Aug. 30, 2007
Pere Clapés Saborit, Vilassar de Dalt, ES;
Jesús Joglar Tamargo, Barcelona, ES;
José Antonio Castillo Expósito, Palau-Solità i Plegamans, ES;
Carles Lozano Pérez, Barcelona, ES;
Pere Clapés Saborit, Vilassar de Dalt, ES;
Jesús Joglar Tamargo, Barcelona, ES;
José Antonio Castillo Expósito, Palau-Solità i Plegamans, ES;
Carles Lozano Pérez, Barcelona, ES;
Consejo Superior de Investigaciones Cientificas, Madrid, ES;
Bioglane, S.L.N.E., Barcelona, ES;
Abstract
The present invention discloses a chemoenzymatic process for the preparation of an iminocyclitol corresponding to formula (I), (II), (III) or (IV), wherein: Rand Rare the same or different, and independently selected from the group consisting of: H, OH, hydroxymethyl, methyl, ethyl, butyl, pentyl, hexyl, octyl, isopropyl, isobutyl, 2-methylbutyl, and benzyl; Ris selected from the group consisting of: H, hydroxymethyl, hydroxyethyl, ethyl, butyl, pentyl, hexyl, octyl, dodecyl, isobutyl, isopropyl, isopentyl, 2-methylbutyl, benzyl, and phenylethyl; n: 0 or 1; the process comprising: (i) an aldol addition catalyzed by a-fructose-6-phosphate aldolase enzyme (FSA) and an acceptor aminoaldehyde; and (ii) an intramolecular reductive amination of the addition adduct obtained in step (i) with H, in the presence of a metallic catalyst, optionally being carried out said step (ii) in the presence of an aldehyde of formula R—CHO, wherein Ris as defined above.