The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2012
Filed:
Mar. 29, 2010
Thomas W. Dubensky, Jr., Piedmont, CA (US);
Dirk G. Brockstedt, Richmond, CA (US);
David N. Cook, Lafayette, CA (US);
Thomas W. Dubensky, Jr., Piedmont, CA (US);
Dirk G. Brockstedt, Richmond, CA (US);
David N. Cook, Lafayette, CA (US);
Aduro Biotech, Inc., Berkeley, CA (US);
Abstract
The present invention providesthat are attenuated for entry into non-phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated. Some of the attenuatedare mutantthat comprise at least one mutation in a gene encoding an invasin, such as an internalin. Some of the attenuatedare further attenuated for cell-to-cell spread. Pharmaceutical compositions and vaccines useful in the methods of the invention are further provided. Methods of making and improving vaccines are also provided.