The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2012
Filed:
Feb. 09, 2010
X. Michael Liu, Pittsford, NY (US);
David J. Heiler, Avon, NY (US);
Thomas Menzel, Rochester, NY (US);
Abbie Brongo, Victor, NY (US);
Susan E. Burke, Batavia, NY (US);
Karl Cummins, Hilton, NY (US);
X. Michael Liu, Pittsford, NY (US);
David J. Heiler, Avon, NY (US);
Thomas Menzel, Rochester, NY (US);
Abbie Brongo, Victor, NY (US);
Susan E. Burke, Batavia, NY (US);
Karl Cummins, Hilton, NY (US);
Bausch & Lomb Incorporated, Rochester, NY (US);
Abstract
A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.