The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2012
Filed:
Apr. 08, 2009
David Gin, New York, NY (US);
Michelle Adams, New York, NY (US);
Kai Deng, Guilderland, NY (US);
Nicholas Perl, New York, NY (US);
Annie Won, Groton, CT (US);
Philip Livingston, New York, NY (US);
Govind Ragupathi, New York, NY (US);
David Gin, New York, NY (US);
Michelle Adams, New York, NY (US);
Kai Deng, Guilderland, NY (US);
Nicholas Perl, New York, NY (US);
Annie Won, Groton, CT (US);
Philip Livingston, New York, NY (US);
Govind Ragupathi, New York, NY (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Abstract
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile