The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2012
Filed:
Oct. 17, 2008
Jean-françois Bonfanti, Andé, FR;
Koenraad Jozef Lodewijk Andries, Beerse, BE;
Jérôme Michel Claude Fortin, Igoville, FR;
Philippe Muller, Andé, FR;
Frédéric Marc Maurice Doublet, Isneauville, FR;
Christophe Meyer, Les Authieux s/l Port St Ouen, FR;
Rudy Edmond Willebrords, Merksplas, BE;
Tom Valerius Josepha Gevers, Vosselaar, BE;
Philip Maria Martha Bern Timmerman, Hasselt, BE;
Jean-François Bonfanti, Andé, FR;
Koenraad Jozef Lodewijk Andries, Beerse, BE;
Jérôme Michel Claude Fortin, Igoville, FR;
Philippe Muller, Andé, FR;
Frédéric Marc Maurice Doublet, Isneauville, FR;
Christophe Meyer, Les Authieux s/l Port St Ouen, FR;
Rudy Edmond Willebrords, Merksplas, BE;
Tom Valerius Josepha Gevers, Vosselaar, BE;
Philip Maria Martha Bern Timmerman, Hasselt, BE;
Janssen Pharmaceutica N.V., , BE;
Abstract
The present invention concerns 5- or 6-substituted-benzimidazole derivatives having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein Q is Ar, R, pyrrolidinyl substituted with R, piperidinyl substituted with Ror homopiperidinyl substituted with R, G is a direct bond or optionally substituted Calkanediyl; Ris Aror a monocyclic or bicyclic heterocycle; one of Rand Ris cyanoCalkyl, cyanoCalkenyl, ArCalkyl, HetCalkyl, N(RR)Calkyl, ArCalkenyl, HetCalkenyl, AraminoCalkyl, HetaminoCalkyl, ArthioCalkyl, HetthioCalkyl, ArsulfonylCalkyl, HetsulfonylCalkyl, Araminocarbonyl, Hetaminocarbonyl, Ar(CH)amino-carbonyl, Het(CH)aminocarbonyl, Arcarbonylamino, Hetcarbonylamino, Ar(CH)carbonylamino, Het(CH)carbonylamino, and the other one of Rand Ris hydrogen; in case Ris hydrogen, then Ris hydrogen;in case Ris hydrogen, the Ris hydrogen or Calkyl. It further concerns their preparation and compositions comprising them, as well as their use as a medicine.