The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2012
Filed:
Jul. 13, 2007
Noritaka Hamada, Tokyo, JP;
Ryo Mizoguchi, Tokyo, JP;
Kuniyuki Sano, Tokyo, JP;
Takaaki Sakaida, Tokyo, JP;
Yuji Awamura, Tokyo, JP;
Yu Iwakawa, Tokyo, JP;
Takahiko Tobe, Tokyo, JP;
Takashi Sugane, Tokyo, JP;
Noritaka Hamada, Tokyo, JP;
Ryo Mizoguchi, Tokyo, JP;
Kuniyuki Sano, Tokyo, JP;
Takaaki Sakaida, Tokyo, JP;
Yuji Awamura, Tokyo, JP;
Yu Iwakawa, Tokyo, JP;
Takahiko Tobe, Tokyo, JP;
Takashi Sugane, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
Object Provided are β-form crystal, γ-form crystal, and α-form crystal of a benzoxadiazole derivative, wherein a uniform crystal having sufficient qualities can be obtained with high reproducibility, and they can be anytime supplied as crystals of drug substance for use in producing pharmaceuticals, are particularly suitable for mass synthesis in industrial production, hardly exhibit hygroscopicity and have particularly excellent photo-resistance. Means for Resolution A solving means includes β-form crystal of 4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole, which shows an endothermic peak at 145 to 150° C. according to a differential scanning calorimeter analysis (DSC analysis) and shows X-ray powder diffraction peaks at 9.8, 11.1, 12.8, 13.3, 17.1, 20.2, 21.2 and 22.3 in 2θ(°), and the like.