The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2012
Filed:
Feb. 21, 2006
Masanori Miyazaki, Kasuya-gun, JP;
Yoshikazu Yonemitsu, Fukuoka, JP;
Yasuhiro Ikeda, Fukuoka, JP;
Katsuo Sueishi, Fukuoka, JP;
Toshiaki Tabata, Tsukuba, JP;
Akihiro Iida, Tsukuba, JP;
Yasuji Ueda, Tsukuba-gun, JP;
Mamoru Hasegawa, Tsukuba, JP;
Masanori Miyazaki, Kasuya-gun, JP;
Yoshikazu Yonemitsu, Fukuoka, JP;
Yasuhiro Ikeda, Fukuoka, JP;
Katsuo Sueishi, Fukuoka, JP;
Toshiaki Tabata, Tsukuba, JP;
Akihiro Iida, Tsukuba, JP;
Yasuji Ueda, Tsukuba-gun, JP;
Mamoru Hasegawa, Tsukuba, JP;
Other;
Abstract
The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.