The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2012
Filed:
Sep. 18, 2007
Tetsuo Yamane, São Paulo SP, BR;
Irina Kerkis, São Paulo SP, BR;
Alexandre Kerkis, São Paulo SP, BR;
Gandhi Rádis Baptista, São Paulo SP, BR;
Mirian Akemi Furuie Hayashi, São Paulo SP, BR;
Katsuhiro Konno, São Paulo SP, BR;
Alvaro Rossan B. P. Da Silva, São Paulo SP, BR;
Lygia Da Veiga Pereira, São Paulo SP, BR;
Eduardo Brandt DE Oliveira, Ribeirão Preto SP, BR;
Tetsuo Yamane, São Paulo SP, BR;
Irina Kerkis, São Paulo SP, BR;
Alexandre Kerkis, São Paulo SP, BR;
Gandhi Rádis Baptista, São Paulo SP, BR;
Mirian Akemi Furuie Hayashi, São Paulo SP, BR;
Katsuhiro Konno, São Paulo SP, BR;
Alvaro Rossan B. P. Da Silva, São Paulo SP, BR;
Lygia da Veiga Pereira, São Paulo SP, BR;
Eduardo Brandt De Oliveira, Ribeirão Preto SP, BR;
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo—FAPESP, Sao Paulo, BR;
Abstract
The present invention refers to uses of crotamine and compositions containing it, based on its characteristic of interaction with genetic material. Under submicromolar quantities, the polypeptide is no longer toxic, presenting the characteristics properties of cell penetration, transport of molecules to the surface, cytoplasm or cell nucleus and particularly, selective cell penetration. The invention also refers to compositions comprising a pharmaceutically effective concentration of crotamine and its use for the treatment of diseases and dysfunctions, based on its characteristics of interaction with genetic material, such as DNA and RNA, and cell selectivity. Further, the invention refers to a kit comprising crotamine as a reagent to: (i) transfect or carry molecules to the surface, cytoplasm or nucleus of the cell or (ii) identify and select actively proliferating cells in a homogeneous and/or mixed cell population, particularly the ones originated from the umbilical cord and/or bone marrow and others undifferentiated cells such as progenitors and stem cells from different sources of organism and cancer cells.