The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2012
Filed:
Sep. 09, 2009
Applicants:
Martin F. Pera, Los Angeles, CA (US);
Tracy L. Zinberg, Long Beach, CA (US);
Kouichi Hasegawa, Pasadena, CA (US);
Inventors:
Martin F. Pera, Los Angeles, CA (US);
Tracy L. Zinberg, Long Beach, CA (US);
Kouichi Hasegawa, Pasadena, CA (US);
Assignee:
University of Southern California, Los Angeles, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to methods of induction and isolation of progenitor cells from stem cell cultures, specifically liver progenitor cells from human embryonic stem cell cultures. In one embodiment, the present invention provides a method of inducing hepatocyte-like progenitor cells by placing a quantity of human embryonic stem cells in a medium supplemented with an inhibitor of the MAPK/MEK/ERK signaling pathway, FGFR, GSK3 and/or BMP.