The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2012
Filed:
Apr. 22, 2009
Matteo Iannacone, Boston, MA (US);
Frank Alexis, Brighton, MA (US);
Pamela Basto, Somerville, MA (US);
Elliott Ashley Moseman, Jamaica Plain, MA (US);
Jinjun Shi, Boston, MA (US);
Robert S. Langer, Newton, MA (US);
Omid C. Farokhzad, Chestnut Hill, MA (US);
Ulrich Von Andrian, Chestnut Hill, MA (US);
Elena Tonti, Riccione, IT;
Matteo Iannacone, Boston, MA (US);
Frank Alexis, Brighton, MA (US);
Pamela Basto, Somerville, MA (US);
Elliott Ashley Moseman, Jamaica Plain, MA (US);
Jinjun Shi, Boston, MA (US);
Robert S. Langer, Newton, MA (US);
Omid C. Farokhzad, Chestnut Hill, MA (US);
Ulrich von Andrian, Chestnut Hill, MA (US);
Elena Tonti, Riccione, IT;
Massachusetts Institute of Technology, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.