The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 02, 2012

Filed:

Jun. 21, 2007
Applicants:

Shigeyuki Tanifuji, Chiba, JP;

Akio Hayashi, Chiba, JP;

Daisaku Nakamura, Chiba, JP;

Shinya Takasaki, Chiba, JP;

Anthony Eamon Storey, Buckinghamshire, GB;

Denis Raymond Christophe Bouvet, Buckinghamshire, GB;

Inventors:

Shigeyuki Tanifuji, Chiba, JP;

Akio Hayashi, Chiba, JP;

Daisaku Nakamura, Chiba, JP;

Shinya Takasaki, Chiba, JP;

Anthony Eamon Storey, Buckinghamshire, GB;

Denis Raymond Christophe Bouvet, Buckinghamshire, GB;

Assignees:

Nihon Medi-Physics Co., Ltd., Tokyo, JP;

GE Healthcare Limited, Little Chalfont, Buckinghamshire, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); C07D 491/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

A compound that has affinity with amyloid, exhibits sufficiently rapid clearance from normal tissues, and is suppressed in toxicity such as mutagenicity is provided, which is represented by the following formula (1): or a salt thereof,wherein Ris a group selected from hydrogen, hydroxyl group, carboxyl group, sulfate group, amino group, nitro group, cyano group, an alkyl substituent with one to 4 carbon atoms or an alkoxy substituent with one to 4 carbon atoms; Ris a radioactive halogen substituent; and m is an integer of 0 to 2, and a low-toxic diagnostic agent for Alzheimer's disease comprising a compound represented by the above formula or a salt thereof is also provided.


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