The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2012
Filed:
Feb. 10, 2012
Tiruvettipuram K. Thiruvengadam, Kendall Park, NJ (US);
Anantha Sudhakar, Fremont, CA (US);
Ngiap Kie Lim, Somerset, NJ (US);
Daw-iong Kwok, Gillette, NJ (US);
George G. Wu, Basking Ridge, NJ (US);
Tao Wang, Springfield, NJ (US);
Mingsheng Huang, Plainsboro, NJ (US);
Michael D. Green, Willingboro, NJ (US);
Tiruvettipuram K. Thiruvengadam, Kendall Park, NJ (US);
Anantha Sudhakar, Fremont, CA (US);
Ngiap Kie Lim, Somerset, NJ (US);
Daw-Iong Kwok, Gillette, NJ (US);
George G. Wu, Basking Ridge, NJ (US);
Tao Wang, Springfield, NJ (US);
Mingsheng Huang, Plainsboro, NJ (US);
Michael D. Green, Willingboro, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence: