The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2012
Filed:
Sep. 14, 2007
Stanley C Bell, Narberth, PA (US);
Glenn Fegley, Eagleville, PA (US);
Stephen Cosenza, Voorhees, NJ (US);
Jodie Duke, Newark, DE (US);
Reddy E Premkumar, Villanova, PA (US);
Reddy M. V. Ramana, Blue Bell, PA (US);
Stanley C Bell, Narberth, PA (US);
Glenn Fegley, Eagleville, PA (US);
Stephen Cosenza, Voorhees, NJ (US);
Jodie Duke, Newark, DE (US);
Reddy E Premkumar, Villanova, PA (US);
Reddy M. V. Ramana, Blue Bell, PA (US);
Onconova Therapeutics, Inc, Newtown, PA (US);
Abstract
Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.