The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2012
Filed:
Apr. 29, 2005
Michael F. T. Koehler, Burlingame, CA (US);
Richard Goldsmith, Belmont, CA (US);
Daniel P. Sutherlin, South San Francisco, CA (US);
Michael F. T. Koehler, Burlingame, CA (US);
Richard Goldsmith, Belmont, CA (US);
Daniel P. Sutherlin, South San Francisco, CA (US);
Curis, Inc., Lexington, MA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A is a carbocycle or heterocycle; X is alkylene, NRC(O), NRC(S), NRC(NH), NRSO, NRSO, NRC(O)NH, NRC(S)NH, C(O)NR, C(S)NR, C(NH)NR, NRPO or NRPO(OH) wherein Ris H or alkyl; Ris selected from the group consisting of alkyl, cycloalkyl, aryl or a heterocycle each of which is optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; Ris halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; Ris halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; m is 0-3; n is 0-3; and salts and solvates thereof. The invention also provides methods of using these compounds for therapy and/or prophylaxis in a mammal of hyperproliferative diseases and angiogenesis mediated diseases due to their activity for inhibiting the hedgehog signaling pathway.