The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2012
Filed:
Dec. 15, 2006
Markus Enzelberger, Planegg, DE;
Stefanie Thiel, München, DE;
Josef Prassler, Germering, DE;
Stefanie Urlinger, München, DE;
Christine Rothe, Dachau, DE;
Markus Enzelberger, Planegg, DE;
Stefanie Thiel, München, DE;
Josef Prassler, Germering, DE;
Stefanie Urlinger, München, DE;
Christine Rothe, Dachau, DE;
MorphoSys AG, Martinsried, DE;
Abstract
The present invention is directed to the preparation and use of a collection of antibody heavy chain complementarity determining region 3 (HCDR) members, where diversity of the collection is a function of the length of the HCDRmembers. The diversity of the collection of HCDRregions substantially represents the natural amino acid distribution of HCDRin the human repertoire. This natural amino acid distribution can be represented by biasing the complete random distribution of amino acids, accordingly, in the HCDRencoding DNA sequence by using trinucleotide mutagenesis (TRIM) technology. A collection of HCDRmembers of the invention each can be comprised within a variable region of an antibody (or fragment thereof) to form a library of synthetic antibodies or antibody fragments. The invention also provides nucleic acid molecules encoding such diverse collection and methods of making and using the same.