The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2012
Filed:
Jul. 22, 2008
Walter Cabri, Rozzano, IT;
Mauro Marzi, Rome, IT;
Fabrizio Giorgi, Ardea, IT;
Elena Badaloni, Rome, IT;
Silvia Armaroli, Gallo Poggio Renatico, IT;
Giuseppe Marazzi, Milan, IT;
Walter Cabri, Rozzano, IT;
Mauro Marzi, Rome, IT;
Fabrizio Giorgi, Ardea, IT;
Elena Badaloni, Rome, IT;
Silvia Armaroli, Gallo Poggio Renatico, IT;
Giuseppe Marazzi, Milan, IT;
Abstract
This invention relates to a process for preparing a crystalline form of (4S)-11(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3'4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing from methanol.