The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 18, 2012

Filed:

Jul. 20, 2011
Applicants:

Dale B. Schenk, Burlingame, CA (US);

Peter A. Seubert, San Francisco, CA (US);

José Saldanha, Middlesex, GB;

Inventors:

Dale B. Schenk, Burlingame, CA (US);

Peter A. Seubert, San Francisco, CA (US);

José Saldanha, Middlesex, GB;

Assignee:

Onclave Therapeutics, Dublin, IE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 39/395 (2006.01); C07H 21/04 (2006.01); C12N 5/07 (2010.01); C12N 5/10 (2006.01); C12N 5/20 (2006.01); C12P 21/08 (2006.01);
U.S. Cl.
CPC ...
Abstract

Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.


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