The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2012
Filed:
Mar. 06, 2009
James F. Rebbeor, Garner, NC (US);
Jonathan S. Strauss, Walnut Creek, CA (US);
Jeffrey A. Yuziuk, Garner, NC (US);
James F. Rebbeor, Garner, NC (US);
Jonathan S. Strauss, Walnut Creek, CA (US);
Jeffrey A. Yuziuk, Garner, NC (US);
Grifols Therapeutics Inc., Research Triangle Park, NC (US);
Abstract
Disclosed is both a method for preparing a plasminogen and a method for preparing a reversibly inactive acidified plasmin by activating the plasminogen. The prepared plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluted at a low pH. The prepared plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.