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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8263597 B1

PDFFull Text
Date of Patent:
Sep. 11, 2012

Filed:

Jul. 18, 2011

Indazole compounds as ccr1 receptor antagonists

Applicants:

Daniel Kuzmich, Danbury, CT (US);

Can Mao, New Milford, CT (US);

Alan David Swinamer, Southbury, CT (US);

David Smith Thomson, Ridgefield, CT (US);

Inventors:

Daniel Kuzmich, Danbury, CT (US);

Can Mao, New Milford, CT (US);

Alan David Swinamer, Southbury, CT (US);

David Smith Thomson, Ridgefield, CT (US);

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:

Michael P. Morris

Anthony P. Bottino

Primary Examiner:

Sun Jae Loewe

Int. Cl.
CPC ...
A61K 31/416 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/5377 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 403/12 (2006.01); C07D 231/56 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 25/00 (2006.01); A61P 3/10 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 37/06 (2006.01); A61P 25/28 (2006.01); A61P 11/06 (2006.01); A61P 13/12 (2006.01); A61P 37/00 (2006.01); A61P 9/10 (2006.01); A61P 19/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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