The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2012
Filed:
Jun. 30, 2010
Ramon E. Poo, Miami, FL (US);
Camillo Ricordi, Miami, FL (US);
Felipe Echeverri, Miami, FL (US);
Over Cabrera, Deerfield Beach, FL (US);
Per-olof Berggren, Miami, FL (US);
Ramon E. Poo, Miami, FL (US);
Camillo Ricordi, Miami, FL (US);
Felipe Echeverri, Miami, FL (US);
Over Cabrera, Deerfield Beach, FL (US);
Per-Olof Berggren, Miami, FL (US);
Biorep Technologies, Inc., Miami, FL (US);
University of Miami, Miami, FL (US);
Abstract
A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.