The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2012
Filed:
Oct. 20, 2008
Hirohito Tsubouchi, Kagoshima, JP;
Hirofumi Uto, Kagoshima, JP;
Takeshi Okanoue, Kyoto, JP;
Yo-ichi Ishida, Miyazaki, JP;
Yuko Sato, Miyazaki, JP;
Masayuki Sudo, Kamakura, JP;
Hirohito Tsubouchi, Kagoshima, JP;
Hirofumi Uto, Kagoshima, JP;
Takeshi Okanoue, Kyoto, JP;
Yo-ichi Ishida, Miyazaki, JP;
Yuko Sato, Miyazaki, JP;
Masayuki Sudo, Kamakura, JP;
Miyazaki Prefectural Industrial Support Foundation, Miyazaki, unknown;
Kagoshima University, Kagoshima, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed against the marker; a diagnostic agent; a diagnosis method; and a method for marker detection in blood or serum. Proteome analysis revealed that quantities of the full-length kininogen and three partial peptides thereof (sequence A: position-440 to position-456, sequence B: position-439 to position-456, and sequence C: position-438 to position-456) in sera of patients with non-alcoholic fatty liver disease are significantly different from those in sera of healthy individuals; and a diagnostic agent and a detecting method for the non-alcoholic fatty liver disease that can be conveniently used for medical examination are established. The use of a combination of a kininogen-based marker and a C4-based marker (the full length sequence or partial peptides thereof) enables identification of chronic hepatitis and an asymptomatic virus carrier, as well as non-alcoholic fatty liver disease.