The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2012
Filed:
Sep. 23, 2008
Applicants:
Michael Fitzpatrick Wempe, Kingsport, TN (US);
Liu Deng, Kingsport, TN (US);
Stephanie Kay Clendennen, Kingsport, TN (US);
Neil Warren Boaz, Kingsport, TN (US);
Inventors:
Michael Fitzpatrick Wempe, Kingsport, TN (US);
Liu Deng, Kingsport, TN (US);
Stephanie Kay Clendennen, Kingsport, TN (US);
Neil Warren Boaz, Kingsport, TN (US);
Assignee:
Eastman Chemical Company, Kongsport, TN (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 8/02 (2006.01); C12P 33/20 (2006.01); C07D 487/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.