The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2012
Filed:
Feb. 04, 2009
Alan Korman, Piedmont, CA (US);
Edward L. Halk, Sunnyvale, CA (US);
Changyu Wang, Union City, CA (US);
Kent B. Thudium, Oakland, CA (US);
Lan Yang, Morgan Hill, CA (US);
Kristopher Toy, San Jose, CA (US);
Alan Korman, Piedmont, CA (US);
Edward L. Halk, Sunnyvale, CA (US);
Changyu Wang, Union City, CA (US);
Kent B. Thudium, Oakland, CA (US);
Lan Yang, Morgan Hill, CA (US);
Kristopher Toy, San Jose, CA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The present invention provides isolated monoclonal antibodies that bind to CTLA-4 and that are capable of increasing the response of T cells to antigenic stimulation in vivo yet the antibodies do not substantially block the binding of CTLA-4 to B7 ligands (e.g., B7-1 and B7-2) in vitro. Thus, the antibodies of the invention demonstrate that is it possible to separate the immunostimulatory function of anti-CTLA-4 antibodies from their ability to block the binding of B7 ligands. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for increasing the response of T cells to antigenic stimulation using the antibodies of the invention, including methods for treating cancer using the antibodies of the invention.