The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2012
Filed:
Jun. 08, 2011
Applicants:
Alain Dlubala, Paris, FR;
Claire Trecant, Strasbourg, FR;
Isabelle Ripoche, Aubiere Cedex, FR;
Inventors:
Assignee:
Sanofi, Paris, FR;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
The disclosure relates to a method for preparing morphine-6-glucuronide or one of the deritives thereof comprising reacting a compound of formula (I): wherein Ris as defined in the disclosure,with a glucuronic acid derivative of formula (II): wherein PG, X, and Rare as defined in the disclosure,in the presence of an aromatic solvent and trimethylsilyl trifluoromethanesulfonate;(ii) reacting the product obtained in step (i) with a strong basic agent; and then (iii) recovering the product obtained in step (ii).