The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 04, 2012

Filed:

Jun. 26, 2009
Applicants:

Takehiro Ishikawa, Azumino, JP;

Satoko Kobayashi, Azumino, JP;

Hitoshi Inoue, Azumino, JP;

Yasunori Ueno, Azumino, JP;

Masako Yoshida, Azumino, JP;

Nobuyuki Tanaka, Azumino, JP;

Inventors:

Takehiro Ishikawa, Azumino, JP;

Satoko Kobayashi, Azumino, JP;

Hitoshi Inoue, Azumino, JP;

Yasunori Ueno, Azumino, JP;

Masako Yoshida, Azumino, JP;

Nobuyuki Tanaka, Azumino, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/04 (2006.01); A61K 31/426 (2006.01); A61K 31/42 (2006.01); A61K 31/381 (2006.01); C07C 205/06 (2006.01); C07D 277/20 (2006.01); C07D 261/06 (2006.01); C07D 333/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein Rand Rare each hydrogen, lower acyl, lower alkoxycarbonyl or the like; Ris lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; Ris cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.


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