The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2012
Filed:
Sep. 21, 2004
Andrew M. Siwkowski, Carlsbad, CA (US);
Edward Wancewicz, Poway, CA (US);
Thomas A. Leedom, Escondido, CA (US);
Lynnetta Watts, Carlsbad, CA (US);
Mausumee Guha, Trabuco Canyon, CA (US);
Brett P. Monia, Encinitas, CA (US);
Andrew M. Siwkowski, Carlsbad, CA (US);
Edward Wancewicz, Poway, CA (US);
Thomas A. Leedom, Escondido, CA (US);
Lynnetta Watts, Carlsbad, CA (US);
Mausumee Guha, Trabuco Canyon, CA (US);
Brett P. Monia, Encinitas, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes SGLT2 and connective tissue growth factor (CTGF) in the kidney.