The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2012
Filed:
Jul. 22, 2009
Reinhard Karge, Staufen, DE;
Ulla Letinois, Saint-Louis, FR;
Gerhard Shiefer, Buggingen, DE;
DSM IP Assets B.V., Heerlen, NL;
Abstract
The present invention is directed to a process for the manufacture of compounds of formula IV wherein Ris an amino protecting group, and Ris hydrogen or Calkyl, comprising a) reacting a compound of formula Ia, wherein Mis a cation, preferably selected from the group consisting of Li, Na+, K, ½ Mgand ½ Zn, (formula 1) with an ammonium salt NHX, wherein Xis an anion, preferably selected from the group consisting of chloride, bromide, sulfate and acetate, in a solvent to a compound of formula II b) reacting a compound of formula II with a nitrile R—CN in the presence of a base to a compound of formula IV. The present invention is further directed to compounds of formula II and their use for the manufacture of vitamin B.