The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2012
Filed:
Mar. 05, 2010
Robert L. Cheek, Mebane, NC (US);
Eric P. Dixon, Cary, NC (US);
Timothy J. Fischer, Raleigh, NC (US);
John W. Groelke, Raleigh, NC (US);
Steven L. Knapp, Apex, NC (US);
Stephen G. Simkins, Fuquay-Varina, NC (US);
Clark M. Whitehead, Apex, NC (US);
Robert L. Cheek, Mebane, NC (US);
Eric P. Dixon, Cary, NC (US);
Timothy J. Fischer, Raleigh, NC (US);
John W. Groelke, Raleigh, NC (US);
Steven L. Knapp, Apex, NC (US);
Stephen G. Simkins, Fuquay-Varina, NC (US);
Clark M. Whitehead, Apex, NC (US);
Tripath Imaging, Inc., Burlington, NC (US);
Abstract
Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.