The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2012
Filed:
Nov. 25, 2008
Tinya Abrams, Emeryville, CA (US);
Paul Barsanti, Emeryville, CA (US);
David Duhl, Emeryville, CA (US);
Michel Faure, Emeryville, CA (US);
Paul A. Renhowe, Danville, CA (US);
Annette Olga Walter, Emeryville, CA (US);
Tinya Abrams, Emeryville, CA (US);
Paul Barsanti, Emeryville, CA (US);
David Duhl, Emeryville, CA (US);
Michel Faure, Emeryville, CA (US);
Paul A. Renhowe, Danville, CA (US);
Annette Olga Walter, Emeryville, CA (US);
Novartis AG, Basel, CH;
Abstract
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.