The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2012
Filed:
Feb. 05, 2008
Erik Karrer, Fremont, CA (US);
Steven H. Bass, Hillsborough, CA (US);
Robert Whalen, Foster City, CA (US);
Philip A. Patten, Portola Valley, CA (US);
Erik Karrer, Fremont, CA (US);
Steven H. Bass, Hillsborough, CA (US);
Robert Whalen, Foster City, CA (US);
Philip A. Patten, Portola Valley, CA (US);
Maxygen, Inc., San Mateo, CA (US);
Abstract
Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.