The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2012
Filed:
Feb. 18, 2010
John C. Hutton, Denver, CO (US);
Richard O'brien, Brentwood, TN (US);
Howard Davidson, Denver, CO (US);
Seija Hackl, Aurora, CO (US);
John C. Hutton, Denver, CO (US);
Richard O'Brien, Brentwood, TN (US);
Howard Davidson, Denver, CO (US);
Seija Hackl, Aurora, CO (US);
Other;
Abstract
A method and compositions for detecting autoimmunity to islet glucose-6-phosphatase related protein (IGRP). Detection of IGRP autoantibodies alone, and in combination with other molecules such as the 65-kDa form of glutamate decarboxylase (GAD), insulin and insulin granule membrane proteins ICA512 (IA-2) and phogrin (IA2β) auto-antigens, provides an effective and reliable chemical assay for the diagnosis of autoimmune (type 1) diabetes. Additionally, this invention provides therapeutic regimens based on IGRP and related molecules for the amelioration of the diabetic clinical condition. Therefore, IGRP alone or in combination with other autioimmune diabetes associated antigens such as insulin, IA-2 and GAD, is useful in the prediction (diagnosis), treatment (therapy), and prevention (prophylaxis) of diabetes.