The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2012
Filed:
Mar. 05, 2008
Masakatsu Hama, Kamisu, JP;
Hiroyuki Konishi, Kamisu, JP;
Takaaki Watanabe, Ibaraki, JP;
Kazuhiro Onozuka, Kamisu, JP;
Shingo Koyama, Kamisu, JP;
Masakatsu Hama, Kamisu, JP;
Hiroyuki Konishi, Kamisu, JP;
Takaaki Watanabe, Ibaraki, JP;
Kazuhiro Onozuka, Kamisu, JP;
Shingo Koyama, Kamisu, JP;
Kao Corporation, Tokyo, JP;
Abstract
The present invention relates to a method for production of a diol form represented by the formula (2), which includes filtering a culture fluid obtained by microbial conversion using a compound represented by the following formula (1a) and/or formula (1b) as a substrate, using a filter having an aperture size of 10 to 100 μm; washing the residue on the filter with water or a solvent having an SP value outside the range of 8.3 to 20 (cal/cm); subsequently dissolving the obtained cake in a solvent having an SP value of 8.3 to 20 (cal/cm); and then filtering or centrifuging the solution. According to the present invention, 1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol, which is useful as an intermediate for the production of 3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furan, can be efficiently produced at high purity.