The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2012
Filed:
Oct. 17, 2006
Tomoko Sekiya, Ibaraki-Ken, JP;
Norimasa Miyamoto, Ibaraki-Ken, JP;
Hirokazu Tanaka, Chiba-Ken, JP;
Kenichi Morita, Ibaraki-Ken, JP;
Naoko Massaki, Ibaraki-Ken, JP;
Tomoko Sekiya, Ibaraki-Ken, JP;
Norimasa Miyamoto, Ibaraki-Ken, JP;
Hirokazu Tanaka, Chiba-Ken, JP;
Kenichi Morita, Ibaraki-Ken, JP;
Naoko Massaki, Ibaraki-Ken, JP;
Eisai R&D Management Co., Ltd., Tokyo, JP;
Abstract
The present invention relates to a screening method for determining whether a substance of interest is a substance which alters GPR40-mediated cell stimulating activities, comprising using a substance of interest, a biomembrane containing GPR40, or cells containing said biomembrane, and phospholipase or salts thereof. According to the present invention, substances involved in insulin secretion can be screened. In addition, according to the present invention, substance useful for the prevention or treatment of diabetes, diabetic complications and degenerative diseases, hyperglycemia, polyuria, ketonemia, acidosis, insulin resistance, impaired glucose tolerance, neurodegenerative diseases, insulinoma, cancers, hyperinsulinemia, hyperglyceridemia, fatty liver, hypoglycemia due to insulin hypersecretion, arteriosclerosis, hyperlipidemia, cerebral stroke, obesity, various diseases induced by diabetes or obesity, and the like.