The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 21, 2012

Filed:

Oct. 17, 2008
Applicants:

Chih Yung Ho, Lansdale, PA (US);

Yan Zhang, Fort Washington, PA (US);

Umar S. M. Maharoof, North Wales, PA (US);

John Harrison, Cambridge, GB;

Jeremy Major, Cambridge, GB;

Svenja Burckhardt, Newmarket, GB;

Alison Jones, Cambridge, GB;

Inventors:

Chih Yung Ho, Lansdale, PA (US);

Yan Zhang, Fort Washington, PA (US);

Umar S. M. Maharoof, North Wales, PA (US);

John Harrison, Cambridge, GB;

Jeremy Major, Cambridge, GB;

Svenja Burckhardt, Newmarket, GB;

Alison Jones, Cambridge, GB;

Assignees:

Janssen Pharmaceutica N.V., Beerse, BE;

Cellzome Limited, Cambridge, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 211/00 (2006.01); C07D 213/72 (2006.01); C07D 213/00 (2006.01); A61K 31/135 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, RR, R, R, R, R, R, R, and Rare provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.


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