The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2012
Filed:
Dec. 23, 2004
Valerio Berdini, Cambridge, GB;
Gordon Saxty, Cambridge, GB;
Marinus Leendert Verdonk, Burwell, GB;
Steven John Woodhead, Cambridge, GB;
Paul Graham Wyatt, Perth, GB;
Robert George Boyle, Cambridge, GB;
Hannah Fiona Sore, Cambridge, GB;
David Winter Walker, Linton, GB;
Ian Collins, Redhill, GB;
Robert Downham, Newmarket, GB;
Robin Arthur Ellis Carr, Bassingbourn, GB;
Valerio Berdini, Cambridge, GB;
Gordon Saxty, Cambridge, GB;
Marinus Leendert Verdonk, Burwell, GB;
Steven John Woodhead, Cambridge, GB;
Paul Graham Wyatt, Perth, GB;
Robert George Boyle, Cambridge, GB;
Hannah Fiona Sore, Cambridge, GB;
David Winter Walker, Linton, GB;
Ian Collins, Redhill, GB;
Robert Downham, Newmarket, GB;
Robin Arthur Ellis Carr, Bassingbourn, GB;
Astex Therapeutics Limited, Cambridge, GB;
Institute of Cancer Research: Royal Cancer Hospital, London, GB;
Cancer Research Technology Limited, London, GB;
Abstract
The invention provides compounds of the formula: (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between Rand NRRand a maximum chain length of 4 atoms extending between E and NRR, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NRRgroup and provided that the oxo group when present is located at a carbon atom a with respect to the NRRgroup; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; Ris an aryl or heteroaryl group; and R, R, Rand Rare as defined in the claims. Also provided are pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents.