The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2012
Filed:
Apr. 21, 2006
Virginia Byers Kraus, Hillsborough, NC (US);
Amy Lynn Mcnulty, Bahama, NC (US);
Eric John Toone, Durham, NC (US);
Virginia Byers Kraus, Hillsborough, NC (US);
Amy Lynn McNulty, Bahama, NC (US);
Eric John Toone, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
Compounds of the formula: are described wherein: Ais ascorbic acid, dehydroascorbic acid, ascorbyl-2-phosphate, an analog thereof, or a salt thereof; L is a linking group coupled to Aat the C5 or C6 position thereof; and Bis an active agent such as an imaging agent or therapeutic agent (e.g. a bisphosphonate), along with pharmaceutically acceptable salts and prodrugs thereof. The compounds are useful for, among other things, improving cartilage uptake of active agents administered for joint diseases such as osteoarthritis and rheumatoid arthritis, and for improving gastrointestinal absorption of bisphosphonates.