The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2012
Filed:
Nov. 24, 2010
Robert B. Perni, Marlborough, MA (US);
Youssef Bennani, Boston, MA (US);
Gregor Zlokarnik, La Jolla, CA (US);
Gerald J. Tanoury, Hudson, MA (US);
Minzhang Chen, Acton, MA (US);
Young Chun Jung, Lexington, MA (US);
Raymond E. Forslund, Natick, MA (US);
Francois Maltais, Tewksbury, MA (US);
Robert B. Perni, Marlborough, MA (US);
Youssef Bennani, Boston, MA (US);
Gregor Zlokarnik, La Jolla, CA (US);
Gerald J. Tanoury, Hudson, MA (US);
Minzhang Chen, Acton, MA (US);
Young Chun Jung, Lexington, MA (US);
Raymond E. Forslund, Natick, MA (US);
Francois Maltais, Tewksbury, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
This invention relates to processes and intermediates for the preparation of salts of deuterated, enantiomericallv enriched alpha-amino beta-hydroxy acids of Formula 1 wherein the variables R,R'and R′are defined herein, and wherein the process may comprise the steps of forming a salt of a compound of Formula 1, and crystallizing said salt to give a compound of greater than 55% enantiomeric excess.