The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2012
Filed:
Sep. 25, 2009
Denis Zaccarin, San Jose, CA (US);
Paul Lundquist, San Jose, CA (US);
Peiqian Zhao, Mountain View, CA (US);
Cheng Frank Zhong, Fremont, CA (US);
Stephen Turner, Menlo Park, CA (US);
Yanqiao Huang, San Mateo, CA (US);
Pezhman Monadgemi, Fremont, CA (US);
Ravi Saxena, San Jose, CA (US);
Annette Grot, Cupertino, CA (US);
Aaron Rulison, Los Altos, CA (US);
Denis Zaccarin, San Jose, CA (US);
Paul Lundquist, San Jose, CA (US);
Peiqian Zhao, Mountain View, CA (US);
Cheng Frank Zhong, Fremont, CA (US);
Stephen Turner, Menlo Park, CA (US);
Yanqiao Huang, San Mateo, CA (US);
Pezhman Monadgemi, Fremont, CA (US);
Ravi Saxena, San Jose, CA (US);
Annette Grot, Cupertino, CA (US);
Aaron Rulison, Los Altos, CA (US);
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Abstract
Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.