The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 21, 2012
Filed:
Oct. 02, 2009
Michael J. Caplan, Woodbridge, CT (US);
H. Kim Bottomly, Wellesley, MA (US);
Howard B. Sosin, Fairfield, CT (US);
A. Wesley Burks, Chapel Hill, NC (US);
Hugh A. Sampson, Larchmont, NY (US);
Michael J. Caplan, Woodbridge, CT (US);
H. Kim Bottomly, Wellesley, MA (US);
Howard B. Sosin, Fairfield, CT (US);
A. Wesley Burks, Chapel Hill, NC (US);
Hugh A. Sampson, Larchmont, NY (US);
University of Arkansas, Little Rock, AR (US);
Mount Sinai School of Medicine of New York University, New York, NY (US);
Allertein Therapeutics, LLC, Fairfield, CT (US);
Abstract
The present invention provides methods and compositions for treating or preventing allergic reactions, particularly anaphylactic reactions. Methods of the present invention involve administering microorganisms to allergic subjects, where the microorganisms contain a recombinant version of the protein allergen. The recombinant version can be wild-type or may include mutations within IgE epitopes of the protein allergen. Preferably the compositions are administered rectally. Particularly preferred microorganisms are bacteria such as. Any allergen may be used in the inventive methods. Particularly preferred allergens are anaphylactic allergens including protein allergens found in foods, venoms, drugs and latex. The inventive compositions and methods are demonstrated in the treatment of peanut-induced anaphylaxis.