The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2012
Filed:
Jun. 23, 2011
Jodie Brice, Florence, SC (US);
Miall Cedilote, Florence, SC (US);
Zhiming Dong, Florence, SC (US);
Pingsheng Zhang, Florence, SC (US);
Jodie Brice, Florence, SC (US);
Miall Cedilote, Florence, SC (US);
Zhiming Dong, Florence, SC (US);
Pingsheng Zhang, Florence, SC (US);
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention provides novel methods for preparing N—(S)-1 -azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 1, a nicotinic α-7 receptor ligand, that are useful for the scaled-up preparation of compound 1. Compound 1 is useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders.