The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2012
Filed:
Aug. 06, 2009
Alan T. Y. Cheng, Naperville, IL (US);
Ying Zhou, Naperville, IL (US);
Balazs Hunek, Chicago, IL (US);
Amitabh Gupta, Naperville, IL (US);
Nigel Grinter, Buffalo Grove, IL (US);
Alan T. Y. Cheng, Naperville, IL (US);
Ying Zhou, Naperville, IL (US);
Balazs Hunek, Chicago, IL (US);
Amitabh Gupta, Naperville, IL (US);
Nigel Grinter, Buffalo Grove, IL (US);
Praxair Technology, Inc., Danbury, CT (US);
Abstract
A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow.