The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2012
Filed:
Jun. 13, 2002
Brigitte Incaurgarat, Lentilly, FR;
Michel Jolivet, Saint Bonnet de Mure, FR;
Odile Letourneur, Sainte Foy les Lynn, FR;
Maria Léonor Nogueira, Toulouse, FR;
Mireille Sebbag, Toulouse, FR;
Guy Serre, Toulouse, FR;
Christian Vincent, Lauzerville, FR;
Brigitte Incaurgarat, Lentilly, FR;
Michel Jolivet, Saint Bonnet de Mure, FR;
Odile Letourneur, Sainte Foy les Lynn, FR;
Maria Léonor Nogueira, Toulouse, FR;
Mireille Sebbag, Toulouse, FR;
Guy Serre, Toulouse, FR;
Christian Vincent, Lauzerville, FR;
Biomerieux, Marcy l'Etoile, FR;
Abstract
A method for detecting anti-filaggrin-autoantibodies specific to rheumatoid arthritis in a biological sample, by providing a filaggrin with no citrulline residues (FNC) having an arginine residue or a filaggrin peptide with no citrulline residues (PFNC) having an arginine residue. Also provided are a citrulline-containing filaggrin (FC) having the peptide sequence of the FNC where some arginine residues have been converted to citrulline residues or a citrulline-containing peptide (PFC) having the peptide sequence of the PFNC, where at least one arginine residue has been converted to a citrulline residue. The sample is contacted with the FNC or PFNC and the FC or PFC, and the resulting immune complexes are detected and quantified, with a value Xand X, respectively. Anti-filaggrin-autoantibodies specific to rheumatoid arthritis are determined to be present in the biological sample if the value of Xis greater than the value of X.