The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 14, 2012
Filed:
Mar. 25, 2005
Masashi Isozaki, Kanagawa, JP;
Keisuke Yoshino, Ann Arbor, MI (US);
Kyoko Taguchi, Kanagawa, JP;
Masayo Kondo, Kanagawa, JP;
Masashi Isozaki, Kanagawa, JP;
Keisuke Yoshino, Ann Arbor, MI (US);
Kyoko Taguchi, Kanagawa, JP;
Masayo Kondo, Kanagawa, JP;
Terumo Kabushiki Kaisha, Shibuya-Ku, Tokyo, JP;
Abstract
A liposome preparation is provided. This liposome preparation is capable of stably encapsulating a drug which is unstable under an acidic condition, and such stable encapsulation is realized without detracting the effect realized by the modification of the membrane by a hydrophilic macromolecule such as stability in blood. More specifically, the liposome preparation comprises a unilamellar vesicle formed from a lipid bilayer comprising a phospholipid as its main membrane component, and an interior aqueous phase of the vesicle at a pH of up to 5. The liposome has a drug loaded therein, and the vesicle is modified with a hydrophilic macromolecule only on its exterior surface.