The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2012
Filed:
Apr. 24, 2007
Jean-charles Quirion, Bourg-Achard, FR;
Geraldine Castle Deliencourt-godefroy, Rouen, FR;
Christophe Audouard, Grand Quevilly, FR;
Jean-Charles Quirion, Bourg-Achard, FR;
Geraldine Castle Deliencourt-Godefroy, Rouen, FR;
Christophe Audouard, Grand Quevilly, FR;
Institut National des Sciences Appliquees de Rouen (INSA), Mont Saint Aignan Cedex, FR;
Abstract
The invention relates to a gem-difluoride glycoconjugated compound with formula (I): where R represents II or a benzyl, acetyl, benzoyl alkyl group, Rand Rmay be identical or different and represent H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl, tertiobutyldiphenylsilyl protective group or an acetal group of the CR'R′ type, where R′ and R′ may be identical or different and represent H or an alkyl, aryl, benzyl or thiophene group, Rrepresents H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, Rrepresents OR″, NGR′GR′, N, or a phthalimide, where R″ represents H or an alkyl, benzyl, benzoyl, acetyl, pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, GR′ and GR′ may be identical or different and represent II or an alkyl, benzyl, benzoyl, acetyl, alkyloxycarbonyl, allyloxycarbonyl or benzyloxycarbonyl group, Rrepresents a free or protected hydroxyl group or a halogen, Rrepresents H or an alkyl, acetyl, benzyl, POH or PONa group. It is applicable to the preparation of compounds that can be used particularly for the treatment of cancer.