The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2012
Filed:
Oct. 25, 2007
Brian L. Hodous, Cambridge, MA (US);
Stephanie D. Geuns-meyer, Medford, MA (US);
Philip R. Olivieri, Charlestown, MA (US);
Vinod F. Patel, Acton, MA (US);
Brian L. Hodous, Cambridge, MA (US);
Stephanie D. Geuns-Meyer, Medford, MA (US);
Philip R. Olivieri, Charlestown, MA (US);
Vinod F. Patel, Acton, MA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to compounds of Formulas I and II, wherein B, B, B, B, C, C, ring D, L, Land Rare defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.