1-adamantyl azetidin-2-one derivatives and drugs containing same

Abstract

It is to provide a novel compound useful for preventing and/or treating diseases that involves 11β-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate. [wherein A ring represents Caryl group, 5- to 14-membered heteroaryl group, Ris a hydrogen atom, halogen atom, Calkoxycarbonyl group, hydroxyl group, carboxyl group or carbamoyl group; Rand Rare the same or different and are a Calkyl group; R, R, and Rare same or different, and are a hydrogen atom, halogen atom, Calkyl group, Calkoxy group, Caryl group, or Rand R, or Rand Rmay together form a Calkylenedioxy group, Rand Rare the same of different and represent a hydrogen atom or Calkyl group, or may together form a Ccyclic hydrocarbon group, n represents an integer of 0 or 1].