The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2012
Filed:
Nov. 30, 2007
Katsumi Aragane, Toyonaka, JP;
Katsuya Ohbuchi, Tsukuba, JP;
Yoshitaka Tamai, Tsukuba, JP;
Naomoto Harada, Tsukuba, JP;
Naomi Murai, Tsukuba, JP;
Yoshiki Ito, Tsukubai, JP;
Jun Kusunoki, Singapore, SG;
Yukina Tokushima, Tsukuba, JP;
Takaharu Maruyama, Tsukuba, JP;
Katsumi Aragane, Toyonaka, JP;
Katsuya Ohbuchi, Tsukuba, JP;
Yoshitaka Tamai, Tsukuba, JP;
Naomoto Harada, Tsukuba, JP;
Naomi Murai, Tsukuba, JP;
Yoshiki Ito, Tsukubai, JP;
Jun Kusunoki, Singapore, SG;
Yukina Tokushima, Tsukuba, JP;
Takaharu Maruyama, Tsukuba, JP;
MSD K.K., Tokyo, JP;
Abstract
It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism.